特聘教授 - 李士元

1.紅外光同調斷層掃瞄系統

利用紅外光以及同調斷層掃描技術(Optical Coherence Tomography, OCT)可以穿透部分牙組織，取得牙齦下牙表面的訊號，經由程式回歸真實位置後再組成三維數位模型，相較於目前市售口掃機，本系統可以在免排齦的情況下，取得製作贋復牙所需之完整磨牙外觀與邊界，結合三維列印系統，便可以發展出獨特的數位贋復製造流程。另外，此系統亦有牙病偵測之發展潛力，可以偵測牙齦下牙結石、二次蛀牙、牙齒微裂縫等不易從表面觀測之疾病。
2.三維列印系統整合研究樹脂與陶瓷類的贋復應用

包含臨時假牙、全口假牙、咬合板、手術導板，以及氧化鋯牙冠的製作。
3.陶瓷、樹脂、與複合材料的合成與其物性的探討

其目的在於改善傳統材料的物性與研發新式的牙科複合材料以適用於臨床。尤其是在牙齒或材料的強度、顏色與光學的表現，以及生物相容性。
4.相關的臨床操作與牙科材料之間的關係

如含氟材料的氟釋放以及再氟化的可行性及雷射於乳牙齲齒治療的應用；不同洗牙機器對復形材料的影響；以不同漂白方式處理牙本質，除了顏色的改變外，同時也造成牙本質硬度的降低；擁有不同單體的聚合物其顏色穩定性與染色能力之相關，及改變樹脂的聚合條件，會影響它的生物相容性與物理性質表現；陶瓷的種類與燒結條件則會影響其顏色與透明度的表現，及抗撓曲強度。

期刊論文（*通訊作者，＃共同作者）

1. Hsu HJ, Lee SY, Jiang CP, Lin R. A comparison of the marginal fit and mechanical properties of a zirconia dental crown using CAM and 3DSP. Rapid Prototyping Journal 2019: Accepted (SCI)

2. Lin CH, Lin YM, Lai YL, Lee SY. Mechanical properties, accuracy and cytotoxicity of the UV-cured 3D printing resins composed of BisEMA, UDMA and/or TEGDMA. Journal of Prosthetic Dentistry 2019: Accepted (SCI).

3. Lin CH, Su JM, Lee SY, Lin YM. Stiffness Modification of Photopolymerizable Gelatin-Methacrylate Hydrogels Influences Endothelial Differentiation of Human Mesenchymal Stem Cells. Journal of Tissue Engineering and Regenerative Medicine 2018: DOI:10.1002/term.2745 (SCI).

4. Lee PH, Yew T L, Lai YL, Lee SY and Chen HL*. Parathyroid hormone gene-activated matrix with DFDBA/collagen composite matrix enhances bone regeneration in rat calvarial bone defects. Journal of the Chinese Medical Association: JCMA 2018; 81(ahead):699-707 (SCI).

5. Chang WT, Hsu HJ, Jiang CP, Lee SY, Lin YM. Effects of titanium dioxide and tartrazine lake on Z-axis resolution and physical properties of resins printed by visible-light 3D printers. RAPID PROTOTYPING JOURNAL 2018; 24(1):160-165 (SCI).

6. Tzeng JJ, Hsiao YT, Wu YC, Chen H, Lee SY, Lin YM. Synthesis, Characterization, and Visible Light Curing Capacity of Polycaprolactone Acrylate. Biomed Research International 2018; 2018: Article ID 8719624, 8 pages (SCI).

7. Lee SY, Wu SC, Chen S, Tsai LL, Tzeng JJ, Lin CH, Lin YM. Synthesis and characterization of polycaprolactone-based polyurethanes for the fabrication of elastic guided bone regeneration membrane. Biomed Research International 2018; 2018: Article ID 3240571, 13 pages (SCI).

8. Lee CY, Chung CC, Chen GJ, Huang CC, Lee SY, Lin YH. Automated Segmentation of Dental Calculus in Optical Coherence Tomography Images. SENSORS AND MATERIALS 2018; 30(11):2517-2529 (SCI).

9. Hsu FJ, Lee SY, Jiang CP. Technical Development of Multi-Resin Three-Dimensional Printer Using Bottom-Up Method. International Journal of Automation and Smart Technology 2018; 8(4):173-178 (OI).

10. Hsu HJ, Lee SY, Chang SK, Jiang CP. Surface Modification of High Density Ceramic Powder for Increasing Suspension Capacity in Three-Dimensional Printing Application. Material Science Forum 2018; 936:159-163 (EI).

11. Lee PH, Chen MY, Lai YL, Lee SY and Chen HL. Human Beta-Defensin-2 and -3 Mitigate the Negative Effects of Bacterial Contamination on Bone Healing in Rat Calvarial Defect. Tissue Engineering 2018; 24(7-8): doi: 10.1089/ten.TEA.2017.0219 (SCI).

12. Hsu HJ, Lee SY, Chang SL*, Lo CH, Lin YM. Shrinkage prediction using finite element analysis and experimental validation using three-dimension slurry printing system.International Journal of Advanced Manufacturing Technology 2017; 91(1-4):1289–1296 (SCI).

13. Lin CH, Chang MC, Hung SC, Lee SY, Lin YM. Bioactive surface modification of polycaprolactone using MG63-conditioned medium can induce osteogenic differentiation of mesenchymal stem cells. Journal of Materials Science 2017; 52(7):3967–3978 (SCI).

14. Chen HH, Lin YC, Lee SY, Chang LY, Chen BJ, Lai YL. Influence of sinus floor configuration on the grafted bone remodeling following osteotome sinus floor elevation. Journal of Periodontology 2017; 88(1):10-16 (SCI).

15. Lin CH, Lee SY, Lin YM. Plasma Treatment in Conjunction with EGM-2 Medium Increases Endothelial and Osteogenic Marker Expressions of Bone Marrow Mesenchymal Stem Cells. Journal of Materials Science 2016; 51(19):9145-54 (SCI).

16. Chung HK, Lee SY. Analysis of Dental Color Matching Devices and Systems. Journal of Family Dentistry 2016; 11(2):5-11 (OI).

17. Lin CH, Lin KF, Mar K, Lee SY, Lin YM. Antioxidant N-acetylcysteine and glutathione increase the viability and proliferation of MG63 cells encapsulated in the gelatin-methacrylate/VA-086/blue light hydrogel system. Tissue Engineering 2016; 22(8):792-800 (SCI).

18. Cheng YC, Lin DH, Jiang CP, Lee SY. Design improvement and dynamic finite element analysis of novel ITI dental implantunder dynamic chewing loads. Bio-Medical Materials and Engineering 2015; 26(S):555-561 (SCI).

19. Chiou YT, Ho YC, Lee SY. Introduction ofDigital Intraoral Scanner. Journal of Family Dentistry 2015; 10(3):4-13 (OI).

20. Chiu Yw, Lee SY, Lin YC, Lai YL. Significance of thewidth of keratinized mucosa on peri-implant health. Journal of the Chinese Medical Association 2015;78:(7);389-394 (SCI).

21. Lin YC, Lee YY, Ho YC, Shieh YC, Lai YL, Lee SY. Treatment of Large Apical Lesions with Mucosal Fenestration: AClinical Study with Long-term Evaluation. Journal of Endodontics 2015; 41(4):563-567 (SCI).

22. Sun Cw, Ho YC, Lee SY. Sensing of ToothMicroleakage Based on Dental Optical Coherence Tomography. Journal of Sensors 2015; http://dx.doi.org/10.1155/2015/984627.

23. Lee SY, Jiang CP. Development of athree-dimensional slurry printing system using dynamic mask projection for fabricating zirconia dental implants. Materials and Manufacturing Processes 2014(575):214-218 (EI).

24. Shih YH, Lin DJ, Chang KW, Hsia SM, Ko SY, Lee SY, Hsue SS, Wang TH, Chen YL, Shieh TM. Evaluation PhysicalCharacteristics and Comparison Antimicrobial and Anti-Inflammation Potentials of Dental Root Canal Sealers Containing Hinokitiol in Vitro. PLOS ONE 2014;9(6): e94941 (SCI).

25. Chou IC, Lee SY, Jiang JP. Effects of implant neck design on primary stability and overload ina type IV mandibular bone. International Journal for Numerical Methods in Biomedical Engineering 2014;30(11):1223-1237 (SCI).

26. Hsu HJ, Lee SY, Jiang CP. Development of maskless-curing slurry stereolithography for fabricatinghigh strength ceramic parts. Advanced Materials Research 2014; 575:214-218 (EI).

27. Jiang CP, Hsu HJ, Lee SY. Development of Mask-less Projection Slurry Stereolithography for the Fabricationof Zirconia Dental Coping. International Journal of Precision Engineering and Manufacturing 2014;15(11):2413-2419 (SCI).

28. Chou IC, Lee SY, Wu MC, Sun CW, Jiang CP. Finite element modelling of implant designs andcortical bone thickness on stress distribution in maxillary type IV bone. Computer Methods in Biomechanics and Biomedical Engineering 2014;17(5):516-526 (SCI).

29. Sun CW, Lee SY, Lin KF. Optical scanningprobe for bioimaging of optical coherence tomography. Journal of Medical and Biological Engineering 2014;34(1):95-100 (SCI).

30. Lin GH, Chang LY, Lin WC, Lee SY, Lai YL. Interdisciplinary approach for treating a largethrough-and-through periapical defect using guided tissue regeneration: A case report with seven-year follow-up. International Journal of Periodontics & Restorative Dentistry 2014;34(1): e1-e8 (SCI).

31. Huang YM, Chou IC, Jiang CP, Wu YS, Lee SY. Finite Element Analysis of Dental Implant Neck Effects on Primary Stability and Osseointegration in a Type IV Bone Mandible. Bio-Medical Materials and Engineering 2014;24(1):1407-1415 (SCI).

32. Lin CS, Hsieh JC, Yeh TC, Lee SY, Niddam DM. Functional dissociation within insular cortex: the effect of pre-stimulus anxiety on pain. Brain Research 2013;1493:40-47 (SCI).

33. Zhuang HB, Tu WS, Pan MC, Wu JW, Chen CS, Lee SY and Yang YC. Noncontact vibro-acoustic detection technique for dental osseointegration examination. Journal of Medical and Biological Engineering 2013;33(1):35-44 (SCI).

34. Pan MC, Zhuang HB, Chen CS, Wu JW, Lee SY. A noncontact resonance frequency detection technique for the assessment of the interfacial bone defect around a dental implant. Medical Engineering & Physics 2013;doi:10.1016/j.medengphy.2013.05.006 (SCI).

35. Hsieh YS, Lee SY, Ho YC, Chuang CC, Tsai JC, Lin KF, Su CW. Dental Optical Coherence Tomography. Sensors 2013; 13(7):8928-8949; doi:10.3390/s130708928 (SCI).

36. Lee WJ, Lai YL, Lee SY. Sleep Bruxism and Associated Physiological Changes. J Dent Sci 2013;31(1):16-26 (OI)

37. Sun CW, Hsieh YS, Ho YC, Jiang CP, Chuang CC, Lee SY.. Characterization of tooth structure and the dentin-enamel zone based on the Stokes-Mueller calculation. Journal of Biomedical Optics 2012;17(11):116026 (1-6) (SCI).

38. Wei YJ, Lin YJ, Kaung SS, Yang SF, Lee SY, Lai YL. Esthetic periodontal surgery for impacted dilacerated maxillary central incisors. American Journal of Orthodontics and Dentofacial Orthopedics 2012;142(4):546-51 (SCI).