教授 - 洪善鈴

姓名:洪善鈴 (HUNG, SHAN-LING)
單純皰疹病毒的致病機轉:單純皰疹病毒(Herpes simplex virus)可引起原發性及潛在性感染,第一型(HSV-1)主要引起口腔感染。本研究室主要利用病毒學、免疫學、細胞及分子生物學等技術,探討HSV-1的致病機轉,包括:病毒感染口腔細胞之影響,及HSV-1與牙周病及牙周致病菌之間可能的關係。
  1. Wu C-Y, Yu Z-Y, Hsu Y-C, Hung S-L*. Enhancing production of herpes simplex virus type 1 in oral epithelial cells by co-infection with Aggregatibacter actinomycetemcomitans. Journal of the Formosan Medical Association 2022; 121(9): 1841-1849. (
  2. Lee Y-Y, Li M-J, Yu Z-Y, Hung S-L*. Modulation of proinflammatory mediators by viruses-bacteria synergism in human osteoblasts-an in vitro study. Journal of the Formosan Medical Association 2022; 121(4): 841-847.
  3. Tsai C-L, Hung S-L, Lee Y-Y, Ho Y-C, Yang S-F*. The role of fibroblasts in the modulation of dental pulp inflammation. Journal of the Formosan Medical Association 2022; 121(1): 342-349.
  4. Wu C-Y, Yu Z-Y, Chen Y-C, Hung S-L*. Effects of epigallocatechin-3-gallate and acyclovir on herpes simplex virus type 1 infection in oral epithelial cells. Journal of the Formosan Medical Association 2021; 120(12): 2136-2143.
  5. Lin H-H, Lin Y-W, Wu C-Y, Hsiao F-P, Lai Y-L*, Hung S-L*. Stimulatory effects of Porphyromonas gingivalis GroEL protein on interleukin-6 and interleukin-8 in human osteoblasts. Journal of the Formosan Medical Association 2021; 120(1): 150-156.
  6. Wu C-Y, He S-J, Mar K, Hsu C-Y S*, Hung S-L*. Inhibition of Streptococcus mutans by a commercial yogurt drink. Journal of Dental Sciences 2019; 14(2):198-205.
  7. Wu C-Y, Su T-Y, Wang M-Y, Yang S-F, Mar K*, Hung S-L*. Inhibitory effects of tea catechin epigallocatechin-3-gallate against biofilms formed from Streptococcus mutans and a probiotic lactobacillus strain. Archives of Oral Biology 2018; 94: 69-77.
  8. Chang C-W, Lin H-H, Wu S-Y, Wu C-Y, Lai Y-L, Hung S-L*. Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment. Journal of the Formosan Medical Association2018; 117(3): 191-196.
  9. Lin Y-C, Wu C-Y, Chang L-Y, Chen C-C, Chen H-H, Lai Y-L*, Hung S-L*. Levels of HMGB1 in gingival crevicular fluid in non-smokers and smokers with chronic periodontitis. Journal of the Formosan Medical Association 2017; 116(12): 933-939.
  10. Cheng C-F, Wu K-M, Chen Y-T, Hung S-L*. Bacterial adhesion to antibiotic-loaded guided tissue regeneration membranes – a scanning electron microscopy study. Journal of the Formosan Medical Association2015; 114(1): 35-45.
  11. Hung S-L, Lee N-G, Chang L-Y, Chen Y-T, Lai Y-L*. Stimulatory effects of glucose and lipopolysaccharide of Porphyromonas gingivalison the secretion of inflammatory mediators from human macrophages. Journal of Periodontology 2014; 85(1):140-149.
  12. Chang L-Y, Lai Y-L, Yu T-H, Chen Y-T, Hung S-L*. Effects of areca nut extract on lipopolysaccharides-enhanced adhesion and migration of human mononuclear leJournal of Periodontology 2014; 85(6): 859-867.
  13. Lin F-Y, Hsiao F-P, Huang C-Y, Shih C-M, Tsao N-W, Tsai C-S, Yang S-F, Chang N-C, Hung S-L* and Lin Y-W*. Porphyromonas gingivalisGroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats. PLoS ONE 2014; 9(7): e102450.
  14. Lee Y-Y, Lin M-B, Cheng C-F, Chang L-Y, Liu T-Y, Hung S-L*. Inhibitory effects of the areca nut extract on expression of complement receptors and Fc receptors in human neutrophils. Journal of Periodontology2014; 85(8): 1096-1106.
  15. Hsu M-J, Hung S-L*. Antiherpetic potential of 6-bromoindirubin-3′-acetoxime (BIO-acetoxime) in human oral epithelial cells. Archives of Virology2013; 158: 1287-1296.
  16. Chang L-Y, Wan H-C, Lai Y-L, Chou I-C, Chen Y-T, Hung S-L*. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress. Archives of Oral Biology2013; 58(10): 1523-1531.
  17. Lee Y-Y, Li Y-C, Hung S-L, Chen Y-C, Lee Y-H, Yang S-F*. Mineral trioxide aggregate induces the release of matrix metalloproteinase-9 by human neutrophils. Journal of Dental Sciences2013; 8: 378-384.
  18. Hung S-L, Chiang H-H, Wu C-Y, Hsu M-J, Chen Y-T*. Effects of herpes simplex virus type 1 infection on immune functions of human neutrophils. Journal of Periodontal Research2012; 47(5): 635-644.
  19. Lee Y-Y, Chan C-H, Hung S-L, Chen Y-C, Lee Y-H, and Yang S-F*. Up-regulation of nucleotide-binding oligomerization domain 1 in inflamed human dental pulp. Journal of Endodontics2011; 37:1370-1375.
  20. Wu S-Y, Chen Y-T, Chen C-W, Chi L-Y, Hsu N-Y, Hung S-L, Ling L-J*. Comparison of clinical outcomes following treatment with guided tissue regeneration using the polylactic acid barrier and the collagen membrane. International Journal of Periodontics & Restorative Dentistry2010; 30(2): 173-179.
  21. Lai Y-L*, Wu C-Y, Lee Y-Y, Chang H-W, Liu T-Y, Hung S-L. Stimulatory effects of areca nut extracts on prostaglandin E2production by human polymorphonuclear leukocytes. Journal of Periodontology 2010; 81: 758-766.
  22. Ho W-H, Lee Y-Y, Chang L-Y, Chen Y-T, Liu T-Y, Hung S-L*. Effects of areca nut extracts on the apoptosis pathways in human neutrophils. Journal of Periodontal Research2010; 45(3):412-420.
  23. Hsu M-J, Wu C-Y, Chiang H-H, Lai Y-L, Hung S-L*. PI3K/Akt signaling mediated apoptosis blockage and viral gene expression in oral epithelial cells during herpes simplex virus infection. Virus Research2010; 153:36-43.
  24. Lu H-H, Chen L-K, Cheng C-Y, Hung S-L, Lin S-C, Chang K-W*. Areca nut extract-treated gingival fibroblasts modulate the invasiveness of polymorphonuclear leukocytes via the production of MMP-2. Journal of Oral Pathology and Medicine2009; 38(1): 79-86
  25. Chang L-Y, Wan H-C, Lai Y-L, Kuo Y-F, Liu T-Y, Chen Y-T, Hung S-L*. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. Journal of Periodontal Research2009; 44: 175-183.
  26. Chang L-Y, Lin J-C, Chang C-W, Ho W-H, Chen Y-T, Peng J-L, Hung S-L*. Inhibitory effects of safrole on phagocytosis, intracellular reactive oxygen species and the activity of myeloperoxidase released by human polymorphonuclear leukocytes. Journal of Periodontology2009; 80: 1330-1337.
  27. Cheng C-F, Lee Y-Y, Chi L-Y, Chen Y-T, Hung S-Land Ling L-J*. Bacterial penetration through the antibiotics-loaded guided tissue regeneration membranes. Journal of Periodontology 2009; 80: 1471-1478.
  28. Chen D-C, Lee Y-Y, Yeh P-Y, Lin J-C, Chen Y-L, Hung S-L*. Eugenol inhibited the antimicrobial functions of neutrophils. Journal of Endodontics 2008; 34(2): 176-180.
  29. Lai Y-L, Lin J-C, Yang S-F, Liu T-Y, Hung S-L*. Areca nut extracts reduced the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. Journal of Periodontal Research2007; 42(1): 69-76.
  30. Chen D-C, Lai Y-L, Lee S-Y, Hung S-Land Chen H-L*. Osteoblastic response to collagen scaffolds varied in freezing temperature and glutaraldehyde crosslinking. Journal of Biomedical Materials Research Part A 2007; 80A: 399-409.
  31. Lee Y-Y, Hung S-L, Pai S-F, Lee Y-H, Yang S-F*. Eugenol suppressed the expression of lipopolysaccharide-induced pro-inflammatory mediators in human macrophages. Journal of Endodontics 2007; 33(6): 698-702.
  32. Hung S-L, Lin Y-J, Chien E-J, Liu W-G, Chang H-W, Liu T-Y, Chen Y-T*. Areca nut extracts-activated secretion of leukotriene B4, and phosphorylation of p38 mitogen-activated protein kinase and elevated intracellular calcium concentrations in human polymorphonuclear leukocytes. Journal of Periodontal Research2007 42(5):393-401.
  33. Lee Y-Y, Yang S-F, Ho W-H, Lee Y-H, Hung S-L*. Eugenol modulates cyclooxygenase-2 expression through the activation of nuclear factor-kappa B in human osteoblasts. Journal of Endodontics 2007; 33(10): 1177-1182.
  34. Hung S-L, Lee Y-Y, Liu T-Y, Peng J-L, Cheng Y-Y, Chen Y-T*. Modulation of phagocytosis, chemotaxis and adhesion of neutrophils by areca nut extracts. Journal of Periodontology2006; 77(4): 579-585.
  35. Chang L-Y, Wan H-C, Lai Y-L, Liu T-Y, Hung S-L*. Enhancing effects of areca nut extracts on production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells. Journal of Periodontology 2006; 77(12): 1969-1977.
  36. Teng Y-C, Chen Y-T, Cheng Y-Y, Hung S-L*. Requirements for the upregulation of interleukin-6 by herpes simplex virus-infected gingival fibroblasts.Viral Immunology 2005; 18(1): 170-178.
  37. Hung S-L, Cheng Y-Y, Peng J-L, Chang L-Y, Liu T-Y, Chen Y-T. Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitansATCC 33384 by neutrophils. Journal of Periodontology 2005; 76(3): 373-379.
  38. Ling L-J, Ho F-C, Chen Y-T, Holborow DW, Liu T-Y, Hung S-L*. Areca nut extracts modulated expression of alkaline phosphatase and receptor activator of nuclear factor κB ligand in osteoblasts. Journal of Clinical Periodontology2005; 32(4): 353-359.
  39. Hung S-L, Lin Y-W, Chen Y-T, Ling L-J. Attachment of periodontal ligament cells onto various antibiotics-loaded guided tissue regeneration membranes.International Journal of Periodontics & Restorative Dentistry 2005; 25(3): 265-275.
  40. Teng Y-C, Chen Y-T, Cheng Y-Y, Hung S-L*. Requirements for the upregulation of interleukin-6 by herpes simplex virus-infected gingival fibroblasts.Viral Immunology 2005; 18(1): 170-178.
  41. Ling L-J, Ho C-C, Wu C-Y, Chen Y-T, Hung S-L*. Association between human herpesviruses and the severity of periodontitis.Journal of Periodontology 2004; 75(11): 1479-1485.
  42. Lai Y-L, Chen Y-T, Lee S-Y, Shieh T-M, Hung S-L*. Cytotoxic effects of dental resin liquids on primary gingival fibroblasts and periodontal ligament cells in vitro. Journal of Oral Rehabilitation2004; 31: 1165-1172.
  43. Ling L-J, Hung S-L, Lee C-F, Chen Y-T, Wu K-M. The influence of membrane exposure on the outcomes of guided tissue regeneration: clinical and microbiological aspects. Journal of Periodontal Research 2003; 38(1): 57-63.
  44. Hung S-L*, Chen Y-L, Chen Y-T. Effects of safrole on the defensive functions of human neutrophils. Journal of Periodontal Research 2003; 38(2): 130-134.
  45. Chen Y-T, Wang Y-H, Cheng Y-Y, Hung S-L*. Direct binding of herpes simplex virus type 1 virions to complement C3. Viral Immunology2003; 16(3): 347-355.
  46. Chen Y-T, Hung S-L, Lin L-W, Chi L-Y, Ling L-J. Attachment of periodontal ligament cells on chlorhexidine-loaded guided tissue regeneration membranes. Journal of Periodontology2003; 74(11): 1652-1659.
  47. Hung S-L*, Wang Y-H, Chen H-W, Lee P-L, Chen Y-T. Analysis of herpes simplex virus entering into cells of oral origin. Virus Research 2002; 86: 59-69.
  48. Hung S-L*, Cheng Y-Y, Wang Y-H, Chang K-W, Chen Y-T. Expression and roles of herpesvirus entry mediators A and C in cells of oral origin. Oral Microbiology and Immunology 2002; 17: 215-223.
  49. Hung S-L, Lin Y-W, Wang Y-H, Chen Y-T, Su C-Y, Ling L-J. Permeability of Streptococcus mutansand Actinobacillus actinomycetemcomitans through guided tissue regeneration membranes and their effects on attachment of periodontal ligament cells. Journal of Periodontology 2002; 73(8): 843-851.
  50. Ling L-J, Hung S-L, Tseng S-C, Chen Y-T, Chi L-Y, Wu K-M, Lai Y-L. Association between betel quid chewing, periodontal status and periodontal pathogens. Oral Microbiology and Immunology 2001; 16: 364-369.
  51. Hung S-L*, Chen Y-L, Wan H-C, Liu T-Y, Chen Y-T, Ling L-J. Effects of areca nut extracts on the functions of human neutrophils in vitro. Journal of Periodontal Research 2000; 35: 186-193.
  52. Hung S-L*, Lee P-L, Chen H-W, Chen L-K, Kao C-L, King C-C. Analysis of the steps involved in Dengue virus entry into host cells. Virology 1999; 257: 156-167.
  53. Gilmartin GM, Hung S-L, DeZazzo JD, Fleming ES, Imperiale MJ. Sequences regulating poly(A) site selection within the adenovirus major late transcription unit influence the interaction of constitutive processing factors with the pre-mRNA. Journal of Virology 1996; 70: 1775-1783.
  54. Hung, S-L, Peng C, Kostavasili I, Friedman HM, Lambris J, Eisenberg RJ, and Cohen G. H. The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway. Virology1994; 203: 299-312.
  55. Hung, S-L, Srinivasan S, Friedman HM, Eisenberg RJ, and Cohen GH. Structural basis of C3b binding by glycoprotein C of Herpes Simplex Virus. Journal of Virology1992; 66: 4013-4027.
  56. Tung FY, Abraham S, Sethna M, Hung S-L, Sethna P, Hogue BG, Brian DA. The 9-kDa hydrophobic protein encoded at the 3′ end of the porcine transmissible gastroenteritis coronavirus genome is membrane-associated. Virology1992; 186: 676-83.
  57. Sethna PB, Hung S-L, Brian DA. Coronavirus subgenomic replicons as a mechanism for mRNA amplification. Advances in Experimental Medicine and Biology 1990; 276: 335-340.
  58. Sethna PB, Hung S-L, Brian DA. Coronavirus subgenomic minus-strand RNAs and the potential for mRNA replicons. Proceedings of the National Academy of Sciences of the United States of America 1989; 86: 5626-5630.