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hungshanling

教授 - 洪善鈴

【基本資料】

姓名：洪善鈴 (HUNG, SHAN-LING)
聯絡電話：(02)2826-7224
辦公室：牙醫館407室
電子郵件：slhung22@nycu.edu.tw
最高學歷：美國賓系法尼亞大學哲學博士 
研究領域：單純皰疹病毒及牙周致病菌的致病機轉

【經歷】

年度
服務單位
服務部門
職稱
2023/02-2023/07
國立陽明交通大學
牙醫學院
代理院長
2021/02-迄今
國立陽明交通大學
口腔生物研究所
教授
2014/02-2018/11
國立陽明大學
教務處
副教務長
2013/02-2014/01
國立陽明大學
牙醫學院
副院長
2006/02-2012/01
國立陽明大學
口腔生物研究所
所長
2002/08-2021/01
國立陽明大學
口腔生物研究所
教授
1995/08-2002/07
國立陽明大學
口腔生物研究所
副教授
1992/08-1994/12
美國密西根大學
微免學系
博士後研究

【榮譽成就】

得獎年度
頒獎單位
獎項名稱
2007
國立陽明大學
榮獲本校96學年度「教學優良獎」

【實驗室研究方向】

單純皰疹病毒的致病機轉：單純皰疹病毒(Herpes simplex virus)可引起原發性及潛在性感染，第一型(HSV-1)主要引起口腔感染。本研究室主要利用病毒學、免疫學、細胞及分子生物學等技術，探討HSV-1的致病機轉，包括：病毒感染口腔細胞之影響，及HSV-1與牙周病及牙周致病菌之間可能的關係。

【研究計畫】

計畫執行年限
計畫名稱
計畫補助單位
計畫擔任工作
2022/08-2023/07
單純皰疹病毒與口腔致病菌的共同感染對於造骨細胞存活及功能的影響
國科會
主持人
2020/08-2022/07
單純皰疹病毒與口腔細菌的感染對於巨噬細胞功能的影響
國科會
主持人
2020/01-2021/07
第一型穿膜黏蛋白與白色念珠菌感染口腔上皮之影響
台北市政府衛生局
主持人

【發表著作】

期刊論文（*通訊作者，＃共同作者）
  1. Wu C-Y, Yu Z-Y, Hsu Y-C, Hung S-L*. Enhancing production of herpes simplex virus type 1 in oral epithelial cells by co-infection with Aggregatibacter actinomycetemcomitans. Journal of the Formosan Medical Association 2022; 121(9): 1841-1849. (https://doi.org/10.1016/j.jfma.2022.01.023).
  2. Lee Y-Y, Li M-J, Yu Z-Y, Hung S-L*. Modulation of proinflammatory mediators by viruses-bacteria synergism in human osteoblasts-an in vitro study. Journal of the Formosan Medical Association 2022; 121(4): 841-847.
  3. Tsai C-L, Hung S-L, Lee Y-Y, Ho Y-C, Yang S-F*. The role of fibroblasts in the modulation of dental pulp inflammation. Journal of the Formosan Medical Association 2022; 121(1): 342-349.
  4. Wu C-Y, Yu Z-Y, Chen Y-C, Hung S-L*. Effects of epigallocatechin-3-gallate and acyclovir on herpes simplex virus type 1 infection in oral epithelial cells. Journal of the Formosan Medical Association 2021; 120(12): 2136-2143.
  5. Lin H-H, Lin Y-W, Wu C-Y, Hsiao F-P, Lai Y-L*, Hung S-L*. Stimulatory effects of Porphyromonas gingivalis GroEL protein on interleukin-6 and interleukin-8 in human osteoblasts. Journal of the Formosan Medical Association 2021; 120(1): 150-156.
  6. Wu C-Y, He S-J, Mar K, Hsu C-Y S*, Hung S-L*. Inhibition of Streptococcus mutans by a commercial yogurt drink. Journal of Dental Sciences 2019; 14(2):198-205.
  7. Wu C-Y, Su T-Y, Wang M-Y, Yang S-F, Mar K*, Hung S-L*. Inhibitory effects of tea catechin epigallocatechin-3-gallate against biofilms formed from Streptococcus mutans and a probiotic lactobacillus strain. Archives of Oral Biology 2018; 94: 69-77.
  8. Chang C-W, Lin H-H, Wu S-Y, Wu C-Y, Lai Y-L, Hung S-L*. Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment. Journal of the Formosan Medical Association2018; 117(3): 191-196.
  9. Lin Y-C, Wu C-Y, Chang L-Y, Chen C-C, Chen H-H, Lai Y-L*, Hung S-L*. Levels of HMGB1 in gingival crevicular fluid in non-smokers and smokers with chronic periodontitis. Journal of the Formosan Medical Association 2017; 116(12): 933-939.
  10. Cheng C-F, Wu K-M, Chen Y-T, Hung S-L*. Bacterial adhesion to antibiotic-loaded guided tissue regeneration membranes – a scanning electron microscopy study. Journal of the Formosan Medical Association2015; 114(1): 35-45.
  11. Hung S-L, Lee N-G, Chang L-Y, Chen Y-T, Lai Y-L*. Stimulatory effects of glucose and lipopolysaccharide of Porphyromonas gingivalison the secretion of inflammatory mediators from human macrophages. Journal of Periodontology 2014; 85(1):140-149.
  12. Chang L-Y, Lai Y-L, Yu T-H, Chen Y-T, Hung S-L*. Effects of areca nut extract on lipopolysaccharides-enhanced adhesion and migration of human mononuclear leJournal of Periodontology 2014; 85(6): 859-867.
  13. Lin F-Y, Hsiao F-P, Huang C-Y, Shih C-M, Tsao N-W, Tsai C-S, Yang S-F, Chang N-C, Hung S-L* and Lin Y-W*. Porphyromonas gingivalisGroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats. PLoS ONE 2014; 9(7): e102450.
  14. Lee Y-Y, Lin M-B, Cheng C-F, Chang L-Y, Liu T-Y, Hung S-L*. Inhibitory effects of the areca nut extract on expression of complement receptors and Fc receptors in human neutrophils. Journal of Periodontology2014; 85(8): 1096-1106.
  15. Hsu M-J, Hung S-L*. Antiherpetic potential of 6-bromoindirubin-3′-acetoxime (BIO-acetoxime) in human oral epithelial cells. Archives of Virology2013; 158: 1287-1296.
  16. Chang L-Y, Wan H-C, Lai Y-L, Chou I-C, Chen Y-T, Hung S-L*. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress. Archives of Oral Biology2013; 58(10): 1523-1531.
  17. Lee Y-Y, Li Y-C, Hung S-L, Chen Y-C, Lee Y-H, Yang S-F*. Mineral trioxide aggregate induces the release of matrix metalloproteinase-9 by human neutrophils. Journal of Dental Sciences2013; 8: 378-384.
  18. Hung S-L, Chiang H-H, Wu C-Y, Hsu M-J, Chen Y-T*. Effects of herpes simplex virus type 1 infection on immune functions of human neutrophils. Journal of Periodontal Research2012; 47(5): 635-644.
  19. Lee Y-Y, Chan C-H, Hung S-L, Chen Y-C, Lee Y-H, and Yang S-F*. Up-regulation of nucleotide-binding oligomerization domain 1 in inflamed human dental pulp. Journal of Endodontics2011; 37:1370-1375.
  20. Wu S-Y, Chen Y-T, Chen C-W, Chi L-Y, Hsu N-Y, Hung S-L, Ling L-J*. Comparison of clinical outcomes following treatment with guided tissue regeneration using the polylactic acid barrier and the collagen membrane. International Journal of Periodontics & Restorative Dentistry2010; 30(2): 173-179.
  21. Lai Y-L*, Wu C-Y, Lee Y-Y, Chang H-W, Liu T-Y, Hung S-L. Stimulatory effects of areca nut extracts on prostaglandin E2production by human polymorphonuclear leukocytes. Journal of Periodontology 2010; 81: 758-766.
  22. Ho W-H, Lee Y-Y, Chang L-Y, Chen Y-T, Liu T-Y, Hung S-L*. Effects of areca nut extracts on the apoptosis pathways in human neutrophils. Journal of Periodontal Research2010; 45(3):412-420.
  23. Hsu M-J, Wu C-Y, Chiang H-H, Lai Y-L, Hung S-L*. PI3K/Akt signaling mediated apoptosis blockage and viral gene expression in oral epithelial cells during herpes simplex virus infection. Virus Research2010; 153:36-43.
  24. Lu H-H, Chen L-K, Cheng C-Y, Hung S-L, Lin S-C, Chang K-W*. Areca nut extract-treated gingival fibroblasts modulate the invasiveness of polymorphonuclear leukocytes via the production of MMP-2. Journal of Oral Pathology and Medicine2009; 38(1): 79-86
  25. Chang L-Y, Wan H-C, Lai Y-L, Kuo Y-F, Liu T-Y, Chen Y-T, Hung S-L*. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. Journal of Periodontal Research2009; 44: 175-183.
  26. Chang L-Y, Lin J-C, Chang C-W, Ho W-H, Chen Y-T, Peng J-L, Hung S-L*. Inhibitory effects of safrole on phagocytosis, intracellular reactive oxygen species and the activity of myeloperoxidase released by human polymorphonuclear leukocytes. Journal of Periodontology2009; 80: 1330-1337.
  27. Cheng C-F, Lee Y-Y, Chi L-Y, Chen Y-T, Hung S-Land Ling L-J*. Bacterial penetration through the antibiotics-loaded guided tissue regeneration membranes. Journal of Periodontology 2009; 80: 1471-1478.
  28. Chen D-C, Lee Y-Y, Yeh P-Y, Lin J-C, Chen Y-L, Hung S-L*. Eugenol inhibited the antimicrobial functions of neutrophils. Journal of Endodontics 2008; 34(2): 176-180.
  29. Lai Y-L, Lin J-C, Yang S-F, Liu T-Y, Hung S-L*. Areca nut extracts reduced the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. Journal of Periodontal Research2007; 42(1): 69-76.
  30. Chen D-C, Lai Y-L, Lee S-Y, Hung S-Land Chen H-L*. Osteoblastic response to collagen scaffolds varied in freezing temperature and glutaraldehyde crosslinking. Journal of Biomedical Materials Research Part A 2007; 80A: 399-409.
  31. Lee Y-Y, Hung S-L, Pai S-F, Lee Y-H, Yang S-F*. Eugenol suppressed the expression of lipopolysaccharide-induced pro-inflammatory mediators in human macrophages. Journal of Endodontics 2007; 33(6): 698-702.
  32. Hung S-L, Lin Y-J, Chien E-J, Liu W-G, Chang H-W, Liu T-Y, Chen Y-T*. Areca nut extracts-activated secretion of leukotriene B4, and phosphorylation of p38 mitogen-activated protein kinase and elevated intracellular calcium concentrations in human polymorphonuclear leukocytes. Journal of Periodontal Research2007 42(5):393-401.
  33. Lee Y-Y, Yang S-F, Ho W-H, Lee Y-H, Hung S-L*. Eugenol modulates cyclooxygenase-2 expression through the activation of nuclear factor-kappa B in human osteoblasts. Journal of Endodontics 2007; 33(10): 1177-1182.
  34. Hung S-L, Lee Y-Y, Liu T-Y, Peng J-L, Cheng Y-Y, Chen Y-T*. Modulation of phagocytosis, chemotaxis and adhesion of neutrophils by areca nut extracts. Journal of Periodontology2006; 77(4): 579-585.
  35. Chang L-Y, Wan H-C, Lai Y-L, Liu T-Y, Hung S-L*. Enhancing effects of areca nut extracts on production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells. Journal of Periodontology 2006; 77(12): 1969-1977.
  36. Teng Y-C, Chen Y-T, Cheng Y-Y, Hung S-L*. Requirements for the upregulation of interleukin-6 by herpes simplex virus-infected gingival fibroblasts.Viral Immunology 2005; 18(1): 170-178.
  37. Hung S-L, Cheng Y-Y, Peng J-L, Chang L-Y, Liu T-Y, Chen Y-T. Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitansATCC 33384 by neutrophils. Journal of Periodontology 2005; 76(3): 373-379.
  38. Ling L-J, Ho F-C, Chen Y-T, Holborow DW, Liu T-Y, Hung S-L*. Areca nut extracts modulated expression of alkaline phosphatase and receptor activator of nuclear factor κB ligand in osteoblasts. Journal of Clinical Periodontology2005; 32(4): 353-359.
  39. Hung S-L, Lin Y-W, Chen Y-T, Ling L-J. Attachment of periodontal ligament cells onto various antibiotics-loaded guided tissue regeneration membranes.International Journal of Periodontics & Restorative Dentistry 2005; 25(3): 265-275.
  40. Teng Y-C, Chen Y-T, Cheng Y-Y, Hung S-L*. Requirements for the upregulation of interleukin-6 by herpes simplex virus-infected gingival fibroblasts.Viral Immunology 2005; 18(1): 170-178.
  41. Ling L-J, Ho C-C, Wu C-Y, Chen Y-T, Hung S-L*. Association between human herpesviruses and the severity of periodontitis.Journal of Periodontology 2004; 75(11): 1479-1485.
  42. Lai Y-L, Chen Y-T, Lee S-Y, Shieh T-M, Hung S-L*. Cytotoxic effects of dental resin liquids on primary gingival fibroblasts and periodontal ligament cells in vitro. Journal of Oral Rehabilitation2004; 31: 1165-1172.
  43. Ling L-J, Hung S-L, Lee C-F, Chen Y-T, Wu K-M. The influence of membrane exposure on the outcomes of guided tissue regeneration: clinical and microbiological aspects. Journal of Periodontal Research 2003; 38(1): 57-63.
  44. Hung S-L*, Chen Y-L, Chen Y-T. Effects of safrole on the defensive functions of human neutrophils. Journal of Periodontal Research 2003; 38(2): 130-134.
  45. Chen Y-T, Wang Y-H, Cheng Y-Y, Hung S-L*. Direct binding of herpes simplex virus type 1 virions to complement C3. Viral Immunology2003; 16(3): 347-355.
  46. Chen Y-T, Hung S-L, Lin L-W, Chi L-Y, Ling L-J. Attachment of periodontal ligament cells on chlorhexidine-loaded guided tissue regeneration membranes. Journal of Periodontology2003; 74(11): 1652-1659.
  47. Hung S-L*, Wang Y-H, Chen H-W, Lee P-L, Chen Y-T. Analysis of herpes simplex virus entering into cells of oral origin. Virus Research 2002; 86: 59-69.
  48. Hung S-L*, Cheng Y-Y, Wang Y-H, Chang K-W, Chen Y-T. Expression and roles of herpesvirus entry mediators A and C in cells of oral origin. Oral Microbiology and Immunology 2002; 17: 215-223.
  49. Hung S-L, Lin Y-W, Wang Y-H, Chen Y-T, Su C-Y, Ling L-J. Permeability of Streptococcus mutansand Actinobacillus actinomycetemcomitans through guided tissue regeneration membranes and their effects on attachment of periodontal ligament cells. Journal of Periodontology 2002; 73(8): 843-851.
  50. Ling L-J, Hung S-L, Tseng S-C, Chen Y-T, Chi L-Y, Wu K-M, Lai Y-L. Association between betel quid chewing, periodontal status and periodontal pathogens. Oral Microbiology and Immunology 2001; 16: 364-369.
  51. Hung S-L*, Chen Y-L, Wan H-C, Liu T-Y, Chen Y-T, Ling L-J. Effects of areca nut extracts on the functions of human neutrophils in vitro. Journal of Periodontal Research 2000; 35: 186-193.
  52. Hung S-L*, Lee P-L, Chen H-W, Chen L-K, Kao C-L, King C-C. Analysis of the steps involved in Dengue virus entry into host cells. Virology 1999; 257: 156-167.
  53. Gilmartin GM, Hung S-L, DeZazzo JD, Fleming ES, Imperiale MJ. Sequences regulating poly(A) site selection within the adenovirus major late transcription unit influence the interaction of constitutive processing factors with the pre-mRNA. Journal of Virology 1996; 70: 1775-1783.
  54. Hung, S-L, Peng C, Kostavasili I, Friedman HM, Lambris J, Eisenberg RJ, and Cohen G. H. The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway. Virology1994; 203: 299-312.
  55. Hung, S-L, Srinivasan S, Friedman HM, Eisenberg RJ, and Cohen GH. Structural basis of C3b binding by glycoprotein C of Herpes Simplex Virus. Journal of Virology1992; 66: 4013-4027.
  56. Tung FY, Abraham S, Sethna M, Hung S-L, Sethna P, Hogue BG, Brian DA. The 9-kDa hydrophobic protein encoded at the 3′ end of the porcine transmissible gastroenteritis coronavirus genome is membrane-associated. Virology1992; 186: 676-83.
  57. Sethna PB, Hung S-L, Brian DA. Coronavirus subgenomic replicons as a mechanism for mRNA amplification. Advances in Experimental Medicine and Biology 1990; 276: 335-340.
  58. Sethna PB, Hung S-L, Brian DA. Coronavirus subgenomic minus-strand RNAs and the potential for mRNA replicons. Proceedings of the National Academy of Sciences of the United States of America 1989; 86: 5626-5630.
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