電子郵件：shuchun@nycu.edu.tw
聯絡電話：(02)2826-7272
最高學歷：美國伊利諾大學哲學博士
專長：生物化學、分子生物學
。學經歷
2014-2018 國立陽明大學 學務長
2012-2014 國立陽明大學 口腔生物研究所 所長
。榮譽成就
2021 中華民國牙醫師公會全國聯合會學術研究獎特優
。實驗室研究方向
研究著重於探討微型RNA (miRNA)、長鏈非轉譯RNA (LncRNA)及環形RNA (circRNA)在口腔癌化之角色及其轉譯意義。先前發現微型RNA miR-31標靶多個抑癌基因，活化缺氧與糖解路徑之致癌角色 (Cancer Res 2010; Cancer Letters 2019)；而miR-211及miR-125b則透過影響PRXL2訊息軸與氧化還原過程，改變口腔癌細胞對藥物之敏感性 (Cancer Res 2016; Redox Biol, 2019)。長鏈非轉譯RNA NEAT1透過NEAT1-miR-125b-SLC1A5調控軸擾亂代謝平衡與粒線體功能，並抑制多種程式化死亡而促進口腔癌化(圖；Cell Death Discov 2024)。相關延續研究近期發現在同一基因座內之miR-31、miR-31宿主基因長鏈非轉譯RNA MIR31HG，與其環形RNA異構體31HGcircR三者之共助致癌功能；且於NUMB及FAT兩個重要抑癌基因中發現多個具有促癌功能，與之拮抗之環形RNA異構體。低溫常壓電漿(CAP)為對正常細胞無害之電漿系統，具有抗癌、抗發炎及促進修復之潛力，近期在小鼠模式發現CAP抑制口腔癌乃透過壓抑生存信息與相關之miRNA表現 (Int J Mol Sci 2023)，目前執行之計畫在探討CAP對口腔癌化進程之預防及口腔癌拮抗CAP之分子機制。
。近五年研究計畫
| 計畫執行年限 | 計畫名稱 | 計畫補助單位 | 計畫擔任工作 |
|---|---|---|---|
| 2024/08/01-2027/07/31 | 以細胞及臨床前模式探討低溫常壓電漿對口腔癌化進程之抑制作用與機制 | 國科會 | 主持人 |
| 2022/08/01-2025/12/31 | 系統性探討FAT家族成員在口腔癌病變的功能(111-2314-B-A49-025-MY3) | 國科會 | 主持人 |
| 2021/08/01-2024/07/31 | 探討鐵凋亡抑制因子在口腔癌化過程及治療之角色 (110-2314-B-A49A-515-MY3) | 國科會 | 主持人 |
| 2019/08/01-2022/07/31 | B7-H4配體在口腔癌調控癌化及免疫逃避之角色(108-2314-B-010-010-MY3) | 國科會 | 主持人 |
。近五年代表著作
- Liu YC, Liu SY, Lin YC, Liu CJ, Chang KW, Lin SC* (2024, Sep). The disruption of NEAT1-miR-125b-5p-SLC1A5 cascade defines the oncogenicity and differential immune profile in head and neck squamous cell carcinoma. Cell Death Discovery, 10, 392.
- Chang SR, Chou CH, Tu HF, Liu CJ, Chang KW*, Lin SC* (2024, May). The expression of immune co-stimulators as a prognostic predictor of head and neck squamous cell carcinomas and oral squamous cell carcinomas. Journal of Dental Sciences, 19: 1380-88.
- Chou CH, Yen CH, Liu CJ, Tu HF, Lin SC*, Chang KW* (2024, Mar). The upregulation of VGF enhances the progression of oral squamous carcinoma. Cancer Cell International, 24:115.
- Cheng YC, Chang, KW, Pan JH, Chen CY, Chou CH, Tu HF, Li WC, Lin SC* (2023, Nov). Cold atmospheric plasma jet irradiation decreases the survival and the expression of oncogenic miRNAs of oral carcinoma cells. International Journal of Molecular Sciences, 24(23):16662.
- Chang SR, Chou CH, Liu CJ, Lin YC, Tu HF, Chang KW*, Lin SC* (2023, Mar). The concordant disruption of B7/CD28 immune regulators predicts the prognosis of oral carcinomas. International Journal of Molecular Sciences, 21;24(6):5931.
- Lin SC, Liu CJ, Ji SH, Hung WW, Liu YC, Chang SR, Tu HF, Chang KW* (2022, Feb). The upregulation of oncogenic miRNAs in swabbed samples obtained from oral premalignant and malignant lesions. Clinical Oral Investigations, 26(2):1343-51.
- Chou CH, Fan Chiang CY, Yang CC, Liu YC, Chang SR, Chang KW*, Lin SC* (2021, Oct). miR-31-NUMB cascade modulates Monocarboxylate Transporters to increase oncogenicity and lactate production of oral carcinoma cells. International Journal of Molecular Sciences, 22(21):11731.
- Chen HH, Yu HI, Rudy R, Lim SL, Chen YF, Wu SH, Lin SC, Yang MH, Tarn WY* (2021, Sep). DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. iScience, 24(9):103086.
- Chang KW, Hung WW, Chou CH, Tu HF, Chang SR, Liu YC, Liu CJ, Lin SC* (2021, Aug). LncRNA MIR31HG drives oncogenicity by inhibiting the Limb-Bud and Heart Development gene (LBH) during oral carcinoma. International Journal of Molecular Sciences, 22(16):8383.
- Chang KW, Lin CE, Tu HF, Chung HY, Chen YF, Lin SC* (2020, Dec). Establishment of a p53 null murine oral carcinoma cell line and the identification of genetic alterations associated with this carcinoma. International Journal of Molecular Sciences, 21(24): 9354.
- Lin SC, Wu HL, Yeh LY, Yang CC, Kao SY, Chang KW* (2020, Dec). Activation of the miR-371/372/373 miRNA cluster enhances oncogenicity and drug resistance in oral carcinoma cells. International Journal of Molecular Sciences, 21(24):9442.
- Yeh LY, Yang CC, Wu HL, Kao SY, Liu CJ, Chen YF, Lin SC*, Chang KW*(2020, Jan). The miR-372-ZBTB7A oncogenic axis suppresses TRAIL-R2 associated drug sensitivity in oral carcinoma. Frontiers in Oncology, 10: 47.