教授 - 林嘉澍

「痛起來要人命」大概是民眾對口腔顏面疾病最深刻的記憶！痛覺是各種情緒與認知因素共同形塑的整體經驗。我們的研究主軸即從腦科學的角度出發，並藉由神經造影探討人腦功能與結構，以了解與疼痛經驗形成有關的中樞神經系統機制，並進一步探索疼痛之診斷與治療方法。我們現階段也將神經造影方法應用於了解探討咀嚼/吞嚥運動的中樞神經機制，期望進一步了解老化對口腔感覺與運動功能的影響。

Dr. Chia-shu Lin is one of the few researchers specializing in both clinical dentistry and human brain science, focusing on neuroimaging. Currently, he is the full-time faculty of the Department of Dentistry as well as the adjunct faculty of the Institute of Brain, National Yang Ming Chiao Tung University (NYCU), Taiwan.

Dr. Lin has pioneered in using neuroimaging methods to study the affective processing of dental patients, with his earlier work on the brain mechanisms of pain catastrophizing. With a series of publications in dental anxiety and the brain, he has been concentrating on the association between pain and anxiety of dental patients for more than 10 years. His research work extended to the oromotor functions of the elderly, including the pioneering work on the brain signatures of masticatory performance and swallowing performance. He has fisrt-authored more than 20 research papers regarding the neuroscience of pain, anxiety, and oromotor functions. On these topics, Dr. Lin has been invited for symposial talks in IADR (2014 and 2017) and organized an incoming IADR symposium (2020) on neuroimaging and translational dentistry. This research work has been shared internationally, via his active connections with global researchers.

 林嘉澍老師的探討人腦與口腔功能的專書著作，Dental Neuroimaging: The Role of the Brain in Oral Functions業已於2021年由國際學術出版權威之一Wiley圖書發行。是國際學界首次聚焦神經造影探討口腔功能人腦機制之專著。

期刊論文（*通訊作者，＃共同作者）

1. Wu L-T, Lin C-S* (Corresponding Author), Yang S-F (2021). Association between pain, anxiety, and pain relief in patients receiving emergent endodontic treatment. Clin Oral Investig, Online ahead of print (IF=3.57, R/C=21/91 (Q1) in DENTISTRY, ORAL SURGERY & MEDICINE).

2. Lin C-S* (Corresponding Author), Lee C-Y, Wu S-Y, Chen L-L, Lee K-T, Wang M-C, Wang T-F (2021). Translation and Validation of Modified Dental Anxiety Scale based on Adult Taiwan Population. BMC Oral Health, accepted (IF=2.76, R/C=35/91 (Q2) in DENTISTRY, ORAL SURGERY & MEDICINE).

3. Lin C-S* (Corresponding Author), Lee C-Y, Chen L-L, Wu L-T, Yang S-F, Wang T-F (2021). Magnification of fear and intention of avoidance in non-experienced vs. experienced dental treatment in adults. BMC Oral Health, 21:328 (IF=2.76, R/C=35/91 (Q2) in DENTISTRY, ORAL SURGERY & MEDICINE).

4. Liu YCG, Lan SJ, Hirano H, Lin, LM, Hori K, Lin CS, Zwetchkenbaum S, Minakuchi S, Teng AYT (2020). Update and review of the gerodontology prospective for 2020’s: Linking the interactions of oral (hypo)-functions to health vs. systemic diseases. Journal of Dental Sciences 16:757 (IF=2.08, R/C=59/91 (Q3) in DENTISTRY, ORAL SURGERY & MEDICINE).

5. Samsir MS, Zakaria R, Razak SA, Ismail MS, Rahim MZA, Lin CS, Osman NMFN, Asri MA, Mohd NH, Ahmad AH (2020). Six Months Guided Exercise Therapy Improves Motor Abilities and White Matter Connectivity in Children with Cerebral Palsy. Malaysian Journal of Medical Sciences 27:90 (IF=0.31, R/C=148/186 (Q1) in MEDICINE, RESEARCH & EXPERIMENTAL).

6. Lo KC, Lin HH, Lin CS* (Corresponding Author) (2020). A novel method for assessing oral mixing ability based on the spatial clusters quantified by variogram. J Oral Rehabil, doi: 10.1111/joor.12954 (IF=3.84, R/C=19/91 (Q1) in DENTISTRY, ORAL SURGERY & MEDICINE).

7. Lin CS, Lin HH, Wang SJ, Fuh JL (2020). Association between regional brain volume and masticatory performance differed in cognitively impaired and non-impaired older people. Experimental Gerontology 137:110942 (IF=4.03, R/C=23/53 (Q2) in GERIATRICS & GERONTOLOGY).

8. Lin CS, Lin HH, Fann SW, Lee WJ, Hsu ML, Wang SJ, Fuh JL (2020). Association between tooth loss and gray matter volume in cognitive impairment. Brain Imaging and Behavior 14:396 (IF=3.98, R/C=5/14 (Q2) in NEUROIMAGING).

9. Lin CS* (Corresponding Author), Yeung AWK (2020). What do we learn from brain imaging?-A primer for the dentists who want to know more about the association between the brain and human stomatognathic functions. Journal of Oral Rehabilitation, 47:5 (IF=3.84, R/C=19/91 (Q1) in DENTISTRY, ORAL SURGERY & MEDICINE).

10. Lin CS* (Corresponding Author) (2020). Functional Adaptation of Oromotor Functions and Aging: A Focused Review of the Evidence From Brain Neuroimaging Research. Frontiers in Aging Neuroscience 11:354 (IF=5.75, R/C=9/53 (Q1) in GERIATRICS & GERONTOLOGY).

11. Lin CS* (Corresponding Author), Wu CY, Wang DH, Lin HH, Lo KC, Lo WL, Liu LK, Fuh JL, Hsu ML (2019). Brain signatures associated with swallowing efficiency in older people. Experimental Gerontology 115:1 (IF=4.03, R/C=23/53 (Q2) in GERIATRICS & GERONTOLOGY).

12. Lee LC, Chen YH, Lin CS, Li WC, Low I, Tu CH, Chou CC, Cheng CC, Yeh TC, Chen LF, Chao HT, Hsieh JC (2018). Unaltered intrinsic functional brain architecture in young women with primary dysmenorrhea. Scientific Reports 8:12971 (IF=4.38, R/C=17/73 (Q1) in MULTIDISCIPLINARY SCIENCES).

13. Lin CS* (Corresponding Author) (2018). Meta-analysis of brain mechanisms of chewing and clenching movements. Journal of Oral Rehabilitation 45:627 (IF=3.84, R/C=19/91 (Q1) in DENTISTRY, ORAL SURGERY & MEDICINE).

14. Lin CS* (Corresponding Author), Wu CY, Wu SY, Lin HH (2018). Brain activations associated with fearful experience show common and distinct patterns between younger and older adults in the hippocampus and the amygdala. Scientific Reports 6:37816 (IF=4.38, R/C=17/73 (Q1) in MULTIDISCIPLINARY SCIENCES).

15. Lin CS* (Corresponding Author) (2018). Revisiting the link between cognitive decline and masticatory dysfunction. BMC Geriatrics 18:5 (IF=3.92, R/C=6/36 (Q1) in GERONTOLOGY).

16. Samsir S, Zakaria R, Razak SA, Ismail MS, Rahim MZA, Lin CS, Osman NMFN, Asri MA, Ahmad AH (2018). Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients. Malaysian Journal of Medical Sciences 25:68 (IF=0.31, R/C=148/186 (Q1) in MEDICINE, RESEARCH & EXPERIMENTAL).

17. Lin CS* (Corresponding Author), Wu CY, Wu SY, Chuang KH, Lin HH, Cheng DH, Lo WL (2017). Age-and sex-related differences in masseter size and its role in oral functions. The Journal of the American Dental Association 148:644 (IF=3.63, R/C=20/91 (Q1) in DENTISTRY, ORAL SURGERY & MEDICINE).

18. Lin CS* (Corresponding Author), Wu CY, Wu SY, Lin HH, Cheng DH, Lo WL (2017). Age-Related Difference in Functional Brain Connectivity of Mastication. Frontiers in Aging Neuroscience 9:82 (IF=5.75, R/C=9/53 (Q1) in GERIATRICS & GERONTOLOGY).

19. Lin CS* (Corresponding Author), Wu SY, CA Yi (2017). Association between Anxiety and Pain in Dental Treatment A Systematic Review and Meta-analysis. Journal of Dental Research 96:153 (IF=6.12, R/C=5/91(Q1) in DENTISTRY, ORAL SURGERY & MEDICINE).

專書

1. Chia-Shu Lin (2021) ，Dental Neuroimaging: The Role of the Brain in Oral Functions，Wiley.

2. 林嘉澍（2009），臨床牙醫師必備 : 病患行為與情緒認知參考手冊。台北市：合記圖書。

3. 林嘉澍譯（2002），分子生物學速成。 (譯自: Instant notes in molecular biology, 2nd ed.P. C. Turner 等原著)。台北市：合記圖書。Conference of Association for Dental Sciences of the Republic of China-Role of disc in function of temporomandibular joint. Taipei, Taiwan, October, 2014.

科普著作

1. 1. 林嘉澍（2020）台灣近五年臨床牙醫研究之國際競爭力 – 以Google Scholar與MEDLINE資料庫為基礎的分析範例科學月刊，263，22-31。

   2. 林嘉澍（2019）思考醫學史上的「痛苦」–是治療傷病還是苦楚？[連結]科學月刊，50(2)，64-69。

   3. 林嘉澍（2018）「人工智慧」起風還是跟風？ – 從口腔醫學研究與牙科教育談起。臺灣牙醫界，37(9)，20-26。

   4. 林嘉澍（2017）「牙科行為科學」在牙醫師養成教育中扮演的角色 – 回顧近年教學之深耕與挑戰。臺灣牙醫界，36(8)，37-47。

   5. 林嘉澍（2017）從腦科學看牙科病人的焦慮與恐懼。科學發展，7，58-63。

   6. 林嘉澍（2017）從腦科學看牙科病人的焦慮與恐懼。科技部「科技大觀園」。

   7. 林嘉澍（2017）當腦神經造影進入你我生活—是超越極限，還是沒有極限。科學月刊，48(4)，306-311。

   8. 郭朝禎（專訪林嘉澍老師）（2016）以人腦造影揭開牙痛的神經機制。科學發展，10，72-73。

   9. 林嘉澍（2013）從臨床診治與教學到口腔健康照顧體系談「牙科焦慮」。臺灣牙醫界，6

   10. 林嘉澍（2012）都是「腦痛」在搗蛋？–談疼痛與焦慮恐懼的人腦神經機制。]科學月刊，43(7)，544-548。

   11. 林嘉澍（2007）安慰劑效應背後的道理。科學月刊，38(9)，702-705。

   12. 林嘉澍（2006）牙科焦慮面面觀。中華牙醫學會訊。，11-12，42-50。

   13. 林嘉澍（2005）牙科臨床病患之疼痛記憶。中華牙醫學會訊。9-10，19-25。

   14. 林嘉澍（2004）淺論安慰劑鎮痛效果及其對於臨床牙科之影響。中華牙醫學會訊。7-8，23-30。

1.亞洲顱顏障礙學會Asian Academy of Cranio-mandibular Disorders （AACMD）/南韓首爾2021.10.23

受邀擔任講者：Association between cultural differences and perception and decision-making about pain

2.臺北榮民總醫院國際醫學教育研討會/台灣台北2021.10.16

受邀擔任研討會講者：Teaching behavioral science and the humanities to dental students – a new model of context-based learning via electronic games

3.第99屆國際牙醫學研究學會年會 International Association for Dental Research (IADR)/美國波士頓2021

擔任研討會主持人(chair)：Neuroimaging and Dentistry: Translational Research based on Brain Imaging

4.第98屆國際牙醫學研究學會年會(IADR)/美國華盛頓2020.3.20

擔任研討會主辦人(organizer) / 受邀擔任研討會講者：Mastication and Deglutition of Geriatric Patients: Mechanisms and Practice

5.第11屆亞太地區老年學暨老年醫學國際研討會 The 11th International Association of Gerontology and Geriatrics Asia/Oceania Regional Congress/台灣台北2019.10.25

受邀擔任講者：New horizon of the gerodontology for 2020: Interactions of oral functions, swallowing and the links to systemic illnesses

6.The 5th Asian Conference for Frailty and Sarcopenia/台灣台北2019.10.23

受邀擔任講者：Masseter Muscle Mass, Frailty and Sarcopenia

7.美國神經科學年會 Neuroscience 2018, Society for Neuroscience (SfN)/美國聖地牙哥2018.11.2

受邀擔任研討會講者：Orofacial Functions: From Neural Mechanisms to Rehabilitation

8.第92屆國際牙醫學研究學會年會(IADR)/英國倫敦2018.7.25

受邀擔任研討會講者：Mastication and Deglutition of Geriatric Patients: Mechanisms and Practice

9.第三屆日本國立長壽醫療研究中心與國衛院高齡與健康整合研究中心討論會/日本名古屋市 2017.9.7

受邀擔任講者：Can chewing make your brain smarter? – Revisiting the current neuroimaging evidence and its clinical implications in geriatric medicine

10.第27屆日本老人齒科學會年會The 27th Annual Meeting of Japanese Society of Gerodontology/日本德島市 2016.6.16

受邀擔任講者：The association between cognitive abilities and masticatory performance in the elderly people: evidence from structural and functional MRI investigation (高齢者の認知能力と咀嚼能率の関係 fMRIによる研究から得られたエビデンス)

11.亞洲顱顏障礙學會Asian Academy of Cranio-mandibular Disorders （AACMD）/南韓大邱2015.10.24

受邀擔任講者：Brain mechanisms associated with masticatory performance in the elderly people

12.第92屆國際牙醫學研究學會年會(IADR)/南非開普敦2014.6.28

受邀擔任symposium講者（Next Generation Imaging in Dentistry：From Pulp to Cortex）：Is dental pain a catastrophe? Functional imaging of pain catastrophizing