螢幕截圖 2022-06-30 09.15.30

副教授 - 林榮辰

姓名:林榮辰 (LIN, JUNG-CHEN)
聯絡電話:
電子郵件: linjungchen@gmail.com
最高學歷:國立台灣大學免疫學研究所博士
研究領域:免疫學、生物工程、免疫治療和疫苗學
年度
服務單位
服務部門
職稱
2024/08-迄今
國立陽明交通大學
口腔組織工程暨生技材料研究所
專任助理教授
2022/02-迄今
國立陽明交通大學
口腔生物研究所
兼任副教授
2016/02-迄今
中央研究院
生物醫學研究所
博士後研究員
2015/02-2016/07
國防醫學院
病理與寄生蟲研究所
兼任助理教授
2015/01-2015/12
匯德生物科技股份有限公司
研發部
研發長
2014/09-2014/12
國立台灣大學
免疫學研究所
博士後研究員
得獎年度
頒獎單位
獎項名稱
2023
財團法人王民寧先生紀念基金會
第33屆王民寧獎:優秀論文獎
2023
第六屆國際再生醫學材料研討會
暨台灣生物材料與控制釋放學會年會
傑出論文獎
2022
科技部
111年度之博士後研究人員學術研究獎
2014
國立台灣大學醫學院
研究生優秀著作獎
利用仿生生物材料來進行免疫工程和免疫調節
計畫執行年限
計畫名稱
計畫補助單位
計畫擔任工作
2022-2024
奈米主軸計畫 增幅mRNA疫苗免疫效性之奈米佐劑研發
科技部
博士後研究員
2019-2022
自然科學及永續研究發展司  個人化奈米抗癌疫苗之製備與優化
科技部
博士後研究員
2016-2019
可裝載佐劑之奈米載體用於流感病毒疫苗的研發
科技部
博士後研究員

(Present – 2019)

(1)  Baghdasaryan, O.#, Khan, S.#, Lin, J.C., Lee-Kin, J., Hsu, C.Y., Hu, C.M.J.* and Tan, C.* 2024. Synthetic control of living cells by intracellular polymerization. Trends Biotechnol 42(2):241-252. (IF=17.3; 3/158; Q1)
 (2)  Lin, C.L.; Fang, Z.S.; Hsu, C.Y.; Liu, Y.H.; Lin, J.C.; Yao, B.Y.; Li, F.A.; Yen, S.C.; Chang, Y.C., and Hu, C.M.J.* 2024. Rapid plasma membrane isolation via intracellular polymerization-mediated biomolecular confinement. Acta Biomater 173:325-335. (IF=9.7; 6/96; Q1)
 (3)  Chien, C.Y., Lin, J.C., Huang, C.Y., Hsu, C.Y., Yang, K.C., Chattopadhyay, S., Nikoloutsos, N, Hsieh, P.C., and Hu, C.M.J.* 2022. In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno-Free Feeder Substrate Engineering. Adv Healthc Mater e2201708. (IF=10; 8/96; Q1)
(4) Yang, K.C., Lin, J.C., Tsai, H.H., Hsu, C.Y., Shih, V, and Hu, C.M.J.* 2021. Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control. Drug Deliv Transl Res 11(4):1420-1437. (IF=5.4; 43/136; Q2)
(5)  Lin, J.C., Hsu, C.Y., Chen, J.Y., Fang, Z.S., Chen, H.W., Yao, B.Y., Shiau, G.H.M, Tsai, J.S., Gu, M., Jung, M.Y., Lee, T.Y., and Hu, C.M.J.* 2021. Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation. Adv Mater 33 (30):2101190. (IF=29.4; 5/178; Q1)
(6)  Chattopadhyay, S, Liu, Y.H., Fang, Z.S., Lin, C.L., Lin, J.C., Yao, B.Y., and Hu, C.M.J.* 2020. Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy. Nano Lett 20:2246-2256. (IF=10.8; 21/178; Q1)
(7)  Lin, L.C.W., Huang, C.Y., Yao, B.Y., Lin, J.C., Agrawal, A., Algaissi, A., Peng, B.H., Liu, Y.H., Huang, P.H., Juang, R.H., Chang, Y.C., Tseng, C.T., Chen, H.W., and Hu, C.M.J.* 2019. Viromimetic STING Agonist-Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus. Advanced Functional Materials 29(28):1807616. (IF=19; 8/178; Q1)
(8)  Lin, J.C., Chien, C.Y., Lin, C.L., Yao, B.Y., Chen, Y.I., Liu, Y.H., Fang, Z.S., Chen, J.Y., Chen, W.Y., Lee, N.N., Chen, H.W., and Hu, C.M.J.* 2019. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nat Commun 10(1):1057. (IF=16.6; 6/73; Q1)

(2018 – 2006)

(9)  Lin, L.C., Chattopadhyay, S, Lin J.C., and Hu, C.M.J.* 2018. Advances and Opportunities in Nanoparticle- and Nanomaterial-Based Vaccines against Bacterial Infections. Adv Healthc Mater 7(13):e1701395. (IF=10; 8/96; Q1)
 (10)  Ka, S.M., Chao, L. K., Lin, J.C., Chen, S.T., Li, W.T., Lin, C.N., Cheng, J.C., Jheng, H.L., Chen A., and Hua, K.F.* 2016. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med 91:10-24. (IF=7.4 ;43/285; Q1)
(11)  Chen, H.W., Huang, C.Y., Lin, S.Y., Fang, Z.S., Hsu, C.H., Lin, J.C., Chen, Y.I., Yao, B.Y., and Hu, C.M.J.* 2016. Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials 106:111-8. (IF=14; 4/96; Q1)
(12)  Ka, S.M., Lin, J.C., Lin, T.J., Liu, F.C., Chao, L.K., Ho, C.L., Yeh, L.T., Sytwu ,H.K., Hua, K.F., Chen, A.* 2015. Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Res Ther 17:331. (IF=4.9; 12/34; Q2)
(13)  Lin, J.C., Lin, S.C., Chen, W.Y., Yen, Y.T., Lai, C.W., Tao, M.H., Lin, Y.L., Miaw. S.C., and Wu-Hsieh, B.A.* 2014. Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development. J Immunol 193:1258-67. (IF=4.4; 77/161; Q2)
(14)  Chang, L.Y., Lin, J.C., Chang, C.W., Ho, W.H., Chen, Y.T., Peng, J.L., and Hung, S.L.* 2009. Inhibitory effects of safrole on phagocytosis, intracellular reactive oxygen species, and the activity of myeloperoxidase released by human polymorphonuclear leukocytes. J Periodontol 80:1330-7. (IF=4.3; 12/91; Q1)
(15)  Chen, D.C., Lee, Y.Y., Yeh, P.Y., Lin, J.C., Chen, Y.L., and Hung, S.L.* 2008. Eugenol inhibited the antimicrobial functions of neutrophils. J Endod 34:176-80. (IF=4.2; 14/91; Q1)
(16)  Lai, Y.L., Lin, J.C., Yang,S.F., Liu, T.Y., and Hung, S.L.* 2007. Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. J Periodontal Res 42:69-76. (IF=3.5; 26/91; Q2)
(17)  Shui, H.A., Ka, S.M., Lin, J.C., Lee, J.H., Jin, J.S., Lin ,Y.F., Sheu, L.F., and Chen, A.* 2006. Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model. Nephrol Dial Transplant 21:1794-802. (IF=6.1; 4/26; Q1)

研討會發表論文

  1. Chung-Yao Hsu, Jung-Chen Lin (林榮辰), Gwo Harn Max Shiau, Bing-Yu Yao, Che-Ming Jack Hu (2023, Aug). Polymerized magnetic cells amenable to synapse formation enable selective capture of antigen-specific T lymphocytes. ISOMRM & BCRS Aug. 31 – Sep. 3 2023, Taipei, Taiwan 2023第六屆台灣國際再生醫學材料應用研討會 暨中華民國生醫材料及藥物制放年會.
  2. Jung-Chen Lin (林榮辰), Chen-Ying Chien, Chi-Long Lin, Chung-Yao Hsu, Jui-Yi Chen, Bing-Yu Yao, Yu- Han Liu, Zih-Syun Fang, Hui-Wen Chen, Che-Ming J. Hu (2023, Aug). Gelated cells as a robust cell-mimicking biomaterial system for cancer immunotherapy and tissue engineering. ISOMRM & BCRS Aug. 31 – Sep. 3 2023, Taipei, Taiwan 2023第六屆台灣國際再生醫學材料應用研討會 暨中華民國生醫材料及藥物制放年會. 本人為第一作者.
  3. Chung-Yao Hsu, Jung-Chen Lin (林榮辰), Gwo Harn Max Shiau, Bing-Yu Yao, Che-Ming Jack Hu (2023, Jul). Polymerized magnetic cells amenable to synapse formation enable selective capture of antigen-specific T lymphocytes. 2023 台灣奈米生醫學會年會暨國際研討會.
  4. Gwo Harn M Shiau, Jeng Fong Chiou, Long-Sheng Lu, Shian Ying Sung, Yin-Ju Chen, Jung-Chen Lin (林榮辰), Chung-Yao Hsu, Che-Ming J. Hu (2023, Jul). Unbiased T cell expansion by cancer taxidermy. 2023 台灣奈米生醫學會年會暨國際研討會.
  5. Chung-Yao Hsu, Lung-Chen Lin (林榮辰) and Che-Ming Jack Hu (2022, Jul). Enabling antigen-specific T cell isolation via active cellular engagement with gelated cellular systems. 台灣奈米生醫學會學會年會暨國際研討會.
  6. Chung-Yao Hsu, Lung-Chen Lin (林榮辰), Wei-Li Liao, Vicky Shih, Che-Ming Jack Hu (2020, Nov). Facile hydrogelation of dendritic cells for rigidity-dependent immune modulation. 臺灣奈米生醫學會年會暨研討會.
  7. Jung-Chen Lin (林榮辰), Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yu-Han Liu, Zih-Syun Fang, Hui-Wen Chen and Che-Ming J. Hu (2019, Dec). Gelated dendritic cells as a robust artificial antigen presenting system for cancer immunotherapy . US-Japan Drug Delivery Symposium . 本人為第一作者.
  8. Jung-Chen Lin (林榮辰), Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yu-Han Liu, Zih-Syun Fang, Hui-Wen Chen and Che-Ming J. Hu (2019, Mar). Preparation of Stable and Effective Artificial Antigen Presenting Cells by Intracellular Hydrogelation . 生醫年會. 本人為第一作者.
  9. Jung-Chen Lin (林榮辰), Shih-Ching Lin, Wen-Yu Chen, Yu-Ting Yen Chin-Wen Lai, Mi-Hua Tao, Yi-Ling Lin, Shi-Chuen Miaw, Betty A. Wu-Hsieh (2015, May). Dengue Viral Protease Interaction with NF-κB Inhibitor α/β Results in Endothelial Cell Apoptosis and Hemorrhage Development. 第12屆財團法人台北市林榮耀教授學術教育基金會論文獎. 本人為第一作者.
內部封定脂質體 (I653990, Taiwan)    2019/03/21
製備搭載胜肽之載體系統的方法 (PCT/US2020/043963)    2021/02/04
自然殺手細胞的放大方法 (I784426, Taiwan)    2022/11/21
人工抗原呈現細胞系統及其用途 (TW202208618A)

教學活動

021-present    基礎免疫學    國立陽明交通大學口腔生物研究所
2015-2020     發炎疾病:以病理學為本探索    國防醫學院病理及寄生蟲研究所
2015-2016    研究所課程    國防醫學院病理部

邀請演講

2024 Polymerizing intracellular cytosol for novel applications in cancer therapy and tissue
         Engineering,國立陽明交通大學牙醫學院
2023 Gelated cells (GCs) as a robust cell-mimicking biomaterial system for biomedicine:
         Present and future applications of GCs, 國防醫學院生物及解剖學研究所
2021 Instilling new life into cells with hydrogels: Present and future applications of gelated
         cells (GCs) in biomedicine, 國立陽明交通大學牙醫學院
2019 Present and future applications of gelated cells (GCs) for biomedicine, 國防醫學院醫學
         科學研究所