【演講】112/5/12(五)中午12:00_臺北醫學大學代謝與肥胖科學研究所助理教授線上演講

30週年口生所所慶暨專題演講第1場-張瀞文助理教授

◎時間：112年5月12日(星期五)中午12:00-13:20

◎實體演講地點：牙醫館320室

◎線上演講連結：https://meet.google.com/pui-izwh-uwz

◎講題：疾病精準醫學的數據挖掘分析(Data mining analyses for precision medicine in diseases)
摘要：Precision medicine uses a patient’s specific clinical, molecular, and lifestyle information to help with disease diagnosis, treatment, and disease prevention. Genetic variations influence our health and respond to medications and other interventions. Precision medicine involves understanding how factors from the environment interact with genetic variations to influence health. My research search for genetic-specific molecular features linked to disease and metabolic profiling as well as proteomic analyses in humans. These analyses will allow us to identify genetic-specific modifiable factors, a helpful knowledge for designing genetic disease prevention strategies, and aid in designing innovative drugs to target disease. One example is nonalcoholic steatohepatitis (NASH) disease. Familial clustering of NASH suggests that this disease is strongly influenced by heritable genetic factors. One of the challenges is that lack of a clear understanding of the genetic predisposition and molecular underpinnings linking NASH-associated HCC. To overcome this challenge, my research program utilized a large systematic search model for genetic defects associated with metabolic syndrome-related NASH. And then integrated genetically engineered mouse models to interrogate the molecular mechanisms of heritable genetic factors on NASH-associated HCC. Over the next 5 years, I will investigate how heritable genetic factors, can change the tumor and host metabolism, various immune cells, fibrosis which can affect the NASH/HCC development.

◎講者：張瀞文助理教授（臺北醫學大學代謝與肥胖科學研究所助理教授、美國國家衛生研究院博士後研究員、陽明交通大學口生所博士後研究員、陽明交通大學口生所第11屆博士班校友）

◎報名連結：

https://docs.google.com/forms/d/1VNgcMZpI_3o8qVX-8cb-mvi9YY-hn9s-Hn5RrsZTInU/edit